MyCog: Rapid detection of cognitive impairment in everyday clinical settings
Cognitive impairment (CI) and dementia are significant public health burdens that can have profound social and emotional effects on older adults. Early detection of CI is imperative in order to identify potentially treatable underlying causal conditions, and in cases where cure is not possible, to provide supportive services to minimize the effects of CI. While primary care and other clinical settings are ideal places for identifying CI, it frequently goes undetected. The availability of screening tools for use in these settings is currently limited, and existing options are often unsuitable for implementation in such settings because of their length, cost, or need for specialized equipment or highly trained administrators. The MyCog project will address this clinical need by developing a brief and standardized set of CI screening measures that is suited for use in diverse settings and with diverse populations.
The MyCog screener will be comprised of two cognitive measures drawn from the NIH Toolbox for Assessment of Neurological and Behavioral Function® and the Everyday Cognition self- and informant-report measures. Available as a downloadable app, MyCog will be validated in a large and diverse sample of adults (ages 65+) who are enrolled in the LitCog Study of Health Literacy and Cognitive Function among Older Adults. In addition to this validation among populations with varying levels of health disparities, it will be an important component of the MyCog project to optimize the screener for use in primary care settings.
Richard Gershon, Principal Investigator, Steering Committee
Michael Wolf, Principal Investigator, Steering Committee, Data Harmonization Committee
David Condon, Steering Committee, Analysis Committee
Marina Arvanitis, Clinical Practice Committee
Laura Curtis, Analysis Committee
Julia Yoshino Benavente, Steering Committee, Clinical Practice Committee
Rachel O’Conor, Data Harmonization Committee
richard gershon, PhD
Vice Chair of Research and Professor of Medical Social Sciences
Northwestern University, Feinberg School of Medicine
In response to the realization that the outcomes tools which he was using in clinical practice were outdated and failed to cover the needs of my patients, Dr. Gershon’s career has increasingly focused on the development of modern assessment tools. He is continuously striving to find new ways to assess outcomes of treatment and methodologies to get that information into the hands of clinicians in a manner that can immediately impact treatment. Over the years and with requests from the NIH, his team has optimized existing and developed dozens of new PRO’s. He actively consults on numerous PRO projects on the behalf of PCORI and the FDA. In his role as Principal Investigator for the NIH Roadmap Patient Reported Outcomes Measurement Information System (PROMIS) Technical Center, Dr. Gershon has served as technology host for more than 2,000 researchers and clinicians who are registered users of AssessmentCenter.net – a test authoring and study administration portal which he created as part of PROMIS I and which now serves as the host for the web-based versions of many instrument systems. As PI for the NIH Toolbox for the Assessment of Neurological and Behavioral Function he created and oversaw a team of over 235 researchers from around the world to create a large battery of instruments for clinical-investigators to assess various areas within cognitive, motor, sensory and emotional health, for longitudinal, clinical and comparative effectiveness research. Dr. Gershon currently serves as MPI for the NIA sponsored grant Advancing Reliable Measurement in Alzheimer’s Disease and cognitive Aging (ARMADA) to validate the NIH Toolbox amongst Alzheimer’s populations and older age groups, as well as for the Environmental influences on Child Health Outcomes (ECHO) PRO Measurement Core where our group recommends, develops and curates assessment delivery for over 80 sites. This background is further augmented by his role as a co-investigator and/or consultant on over 100 assessment development projects in health care, education and certification.
michael wolf, ma, mph, phd
Professor of Medicine
Northwestern University, Feinberg School of Medicine
Dr. Wolf is a health services researcher with expertise in health literacy, aging, chronic disease self-management specific to medication safety and adherence, and the design of health system interventions to promote health. For the past 18 years, Dr. Wolf has led numerous NIH, AHRQ, CDC, private foundation and industry-sponsored studies investigating 1) individual and health system determinants of health services use and outcomes, and 2) the effectiveness and fidelity of interventions aimed at helping patients better engage in self-care tasks beyond the point of care. In 2004, he founded the Health Literacy & Learning Program (HeLP) to create a network of multidisciplinary faculty that could partner together to generate applied, innovative research that would help transform the delivery of healthcare for vulnerable patients. The HeLP network includes faculty across several Northwestern medical and surgical departments, schools (Communication, Education & Social Policy, Engineering, Liberal Arts & Sciences), community partners, and other academic institutions and healthcare organizations around the nation and globally. Since 2009, Dr. Wolf has also served as Associate Division Chief for General Internal Medicine & Geriatrics. His role has been to further develop our Division’s health services and outcomes research agenda. In 2014, he was also appointed as Associate Vice Chair for Research for the Department of Medicine, with a similar goal to catalyze health services research across all clinical divisions.
David Condon, PhD
David Condon is an Assistant Professor in the Department of Medical Social Sciences at Northwestern University. His research program is focused on the structure and assessment of individual differences (e.g., cognition, personality, and physical/mental/social functioning) and related psychosocial measurement topics. This work includes both the development of tools for use in clinical settings and the translation of findings from individual differences research to advance personalized healthcare. In light of increasing evidence that individual differences can help to predict, prevent, and treat chronic illnesses, Dr. Condon is especially focused on the development of empirically-informed, person-centered measures that relate to common diseases such as mild cognitive impairment and dementia, cardiovascular disease, and diabetes. To support the development of these tools, Dr. Condon has co-led the development of a large-scale data collection platform (the SAPA-Project) that aims to identify and clarify the associations between health behaviors and other behavioral individual differences. Data collected through the SAPA-Project have led to the development of the International Cognitive Ability Resource (a public-domain library of cognitive ability measures available for use in online assessments) and the SAPA Personality Inventory (a hierarchically-organized personality assessment tool). He has also contributed to the development of scales for patient engagement and imaginative capacity. As an advocate for the use of transparent and reproducible research methods, Dr. Condon has developed considerable expertise in the publication and management of open data and is a member of the Steering Committee for PsyArXiv, a free preprint service for the psychological sciences.
Marina Arvanitis, MD, MPH
Marina Arvanitis, MD, MPH is a primary care internist and pediatrician, and a health services researcher focusing on health literacy, patient-reported outcomes, and health care quality. She is particularly interested in understanding the life course development of health literacy, including the role that cognition plays in this development, as well as the effects of health literacy on individual and family health, and how it can be promoted within families. Dr. Arvanitis completed a combined Internal Medicine and Pediatrics residency at the Medical College of Wisconsin, and a National Research Service Award Primary Care Research Fellowship at the Cecil G. Sheps Center for Health Services Research at the University of North Carolina at Chapel Hill. She is now an assistant professor at Northwestern University, where she is a researcher in the Health Literacy and Learning Program (HeLP), and provides primary care for adults and children at Northwestern Medical Group and the Lurie Children’s Hospital of Chicago.
Laura Curtis, MS
Laura Curtis, MS is a Research Assistant Professor in the Division of General Internal Medicine and Geriatrics at Northwestern University. She has worked as research scientist and statistical analyst with the Health Literacy and Learning Program (HeLP) for over 10 years. Her research focuses on examining the measurement of health literacy and cognition and their roles in patients’ ability to self-manage their health and improve functional health outcomes. Ms. Curtis has her Master’s degree in biostatistics and currently directs HeLP’s Data Analysis Unit where she supervises data analysts and programmers.
Julia Yoshino Benavente, MPH
Julia Yoshino Benavente, MPH is a Research Project Manager in the Division of General Internal Medicine and Geriatrics at Northwestern University. She received her MPH in Epidemiology and Maternal and Child Health from the University of Washington and has over ten years of research coordination and research project management experience in the fields of early phase oncology, pediatric infectious diseases, and health services research. Ms. Yoshino Benavente has been working with Dr. Michael Wolf and his team in the Health Literacy and Learning Program (HeLP) at Northwestern for the past four years and manages the program’s cognitive aging research portfolio.
Rachel O'Conor, MPH
Rachel O’Conor, MPH is a Clinical Research Associate within the Division of General Internal Medicine and Geriatrics at the Northwestern University Feinberg School of Medicine, and doctoral candidate in Public Health. Her research focuses on psychosocial and cognitive determinants of chronic disease self-management behaviors and health outcomes among older adults, and is interested in the design of health system interventions to promote self-management behaviors and health outcomes among individuals with chronic illness, particularly for adults who experience significant social and economic hardship and shoulder an unequal burden of many conditions. She has worked with the Health Literacy and Learning Program for the past 9 years and directs the program’s chronic disease self-management research portfolio.